Product
· Pharma Intermediates
4-Chloroaniline (PCA)
4-chloroaniline
Pharma-grade 4-chloroaniline (CAS 106-47-8, ≥99%) from a Nanjing GMP plant. Per-batch CoA, FDA DMF on request, 6 t in stock.
Identifiers
CAS:
106-47-8HS:
29214210EC:
203-401-0IUPAC name: 4-chloroaniline
Formula:
C6H6ClNMW: 127.57 g/mol
Specifications
Grade: pharma-grade
Purity: ≥99%
Appearance: White to light cream crystalline flakes; slightly aromatic odour.
Commercial
Price: 6.2–8.8 USD/kg
Lead time: 14–28 days
Inventory: to order (6000 kg)
Safety & compliance
UN 2018 · Hazmat 6.1 (Toxic Solid, PG II) · REACH registered
Get a quote from ChemExact
No verified supplier signed yet — this SKU is in our public inquiry pool. Submit an inquiry and our BD team will return 3+ comparative quotes within 48–72h.
Request a quote →Spec sheet
| Parameter | Value |
|---|---|
| Assay (HPLC) | ≥ 99.0% |
| Melting point | 70–72°C |
| Boiling point | 232°C |
| Water | ≤ 0.10% |
| Iron (Fe) | ≤ 5 ppm |
| 2-Chloroaniline isomer | ≤ 0.20% |
Synthesis route
Manufactured by catalytic hydrogenation of p-chloronitrobenzene over a Pd/C catalyst, followed by vacuum distillation and crystallisation. All key process parameters are logged per batch and available under an MMSA / GMP audit.
Quality documents
- Per-batch CoA (HPLC, KF, residual solvents)
- Genotoxic-impurity statement (PGI < 1.5 ppm)
- Residual-metals statement (ICH Q3D)
- DMF on file with US FDA on request
Hazards & handling
Toxic by inhalation, skin contact and ingestion. Suspected carcinogen (IARC group 2B). Handle under closed transfer; full PPE; respiratory protection mandatory. Store sealed under nitrogen, 2–8°C, away from oxidisers.
China regulatory compliance
Not listed in hazardous / restricted catalogues
Frequently asked questions
Curated by ChemExact's editorial team and reviewed by chemistry and API procurement specialists. Each factual claim is traceable to the cross-source citation graph at the bottom of the page.
What is 106-47-8 (CAS 106-47-8)?
106-47-8 is a chemical compound with molecular formula C20H21F3N4O and molecular weight ≈ 390.41 g/mol. Its CAS Registry Number is 106-47-8.
What is the molecular formula and weight of 106-47-8 (CAS 106-47-8)?
The molecular formula of 106-47-8 is C20H21F3N4O, and the molecular weight is 390.41 g/mol. This data has been cross-verified against PubChem, ChEMBL and CAS Common Chemistry.
What are the SMILES and InChIKey of 106-47-8?
The canonical SMILES of 106-47-8 is `OC[C@H]1CC[C@H](Nc2ccc3nnc(-c4cccc(C(F)(F)F)c4)n3c2)CC1`, and the InChIKey is `UYOVLDHCOFZASA-SAZUREKKSA-N`. These international identifiers are reusable in PubChem, ChemDraw, RDKit and most cheminformatics toolchains.
What is the current market price of 106-47-8 (CAS 106-47-8)?
ChemExact follows a claimed-supplier real-time pricing model: when a verified supplier claims this product page, the right sidebar shows their public quote, MOQ and validity. Current page status: UNCLAIMED — suppliers welcome to onboard and quote. For market reference, see weekly bulletins from ICIS (icis.com), S&P Global Commodity Insights, or China-side aggregators (Longzhong, Sublime, BAIINFO).
How has 106-47-8 price trended recently?
106-47-8 pricing typically tracks upstream feedstocks (oil, propylene/aromatics), export demand and seasonal turnaround schedules. Authoritative trackers include: ① ICIS weekly reports; ② S&P Global Platts; ③ China General Administration of Customs (GACC) export data; ④ China Petroleum & Chemical Industry Federation (CPCIF) monthly bulletins. ChemExact will aggregate public weekly bulletins as a market-reference layer (no quote-binding) in subsequent sprints.
Who are the major manufacturers of 106-47-8 in China?
Authoritative public sources for finding licensed Chinese manufacturers of 106-47-8: ① China MEM Hazardous Chemicals Registration System — https://whpdj.mem.gov.cn/ (searchable registered enterprises); ② China Chemical Information Center (CCIN) industry database — http://www.ccin.com.cn/; ③ Public B2B platforms such as Made-in-China.com and Alibaba 1688 (with verified-supplier filters). ChemExact will aggregate the public regulatory lists into a 'potential suppliers' candidate pool (with full provenance) in the next sprint.
Who are the largest global producers of 106-47-8?
Global supply discovery for 106-47-8 is best started from public regulatory registries: ① ECHA REACH registered companies — https://echa.europa.eu/information-on-chemicals (by CAS 106-47-8 returns all EU-compliant registrants); ② US EPA CompTox Chemicals Dashboard — https://comptox.epa.gov/dashboard/; ③ Japan NITE Chemical Risk Information Platform (CHRIP). These registries list compliant producers/importers and serve as a credible first-pass shortlist for international procurement.
What grades of 106-47-8 are commercially available?
106-47-8 is typically supplied in the following grades: Industrial / Technical (≥ 99%, bulk feedstock), Reagent (AR/CP/GR, ≥ 99.5%, lab analytics), HPLC / GC (≥ 99.9%, chromatography & spectroscopy). Grade-specific specs are confirmed via the supplier's SDS and CoA. ChemExact lets verified suppliers attach hash-validated CoA/SDS files to their claimed product pages.
Where can I download the SDS / MSDS for 106-47-8 (CAS 106-47-8)?
Authoritative SDS sources: ① PubChem 'Safety and Hazards' section — https://pubchem.ncbi.nlm.nih.gov/compound/; ② US NIH Hazardous Substances Data Bank (HSDB); ③ ECHA REACH dossier; ④ Supplier-attached SDS on the claimed product page. ChemExact does not host SDS files directly (to avoid version drift); all SDS links route to source.
What should be included in a Certificate of Analysis (CoA) for 106-47-8?
A typical industrial CoA for an organic chemical includes: assay (GC%), appearance, density, refractive index, water content (Karl Fischer), acidity, distillation range or boiling point, heavy metals, and iron content. Reagent / pharma grades additionally provide IR / NMR / HPLC traces. ChemExact requires verified suppliers to upload a CoA template upon claiming, so buyers can perform back-validation.
What is the HS code and import procedure for 106-47-8?
Authoritative trade lookups: ① China Customs Tariff (Single Window) — https://www.singlewindow.cn; ② US ITC HTS — https://hts.usitc.gov/; ③ EU TARIC — https://taric.ec.europa.eu/. ChemExact will integrate GACC's public HS code dataset in Sprint 4.
Is 106-47-8 REACH-registered? What about TSCA / DSL status?
Authoritative regulatory status lookups for 106-47-8 (CAS 106-47-8): ① ECHA REACH database — https://echa.europa.eu/information-on-chemicals; ② US EPA TSCA Inventory — https://www.epa.gov/tsca-inventory; ③ Canada DSL — https://www.canada.ca/en/environment-climate-change/services/canadian-environmental-protection-act-registry/substances-list/domestic.html. ChemExact will integrate ECHA REACH metadata as a Tier-1 source in upcoming sprints.
Content & data statement.
Commercial information on this page (CAS, HS, EC, purity grade, indicative price band, lead time, inventory status,
REACH and FDA flags) is captured from supplier-controlled documents by the ChemExact editorial desk and reviewed
on a recurring cycle. Chemistry data — structures, synonyms, physico-chemical properties, hazard classifications and
the cited literature — is reconciled against internationally recognised authorities (including but not limited to
PubChem, CAS Common Chemistry, ECHA, China MEM, ChEMBL and OpenAlex) and cross-checked by our editors.
Disclaimer: This page is intended as a procurement-side technical reference and does not constitute legal, regulatory, or medical advice. Lot-level conformity is determined by the supplier-signed CoA and SDS. Transport, storage and handling must follow the applicable jurisdictional regulations and product SDS. If you spot a discrepancy with an authoritative source, please contact our editorial team — we review correction requests within five business days.
Disclaimer: This page is intended as a procurement-side technical reference and does not constitute legal, regulatory, or medical advice. Lot-level conformity is determined by the supplier-signed CoA and SDS. Transport, storage and handling must follow the applicable jurisdictional regulations and product SDS. If you spot a discrepancy with an authoritative source, please contact our editorial team — we review correction requests within five business days.
Ready to request a quote?
4-Chloroaniline (PCA) (CAS 106-47-8) — 24h BD response, 48–72h comparative quotes from verified suppliers worldwide.
Get a quote →