Product
· Pharma Intermediates
4-Chloroaniline (PCA)
4-chloroaniline
Pharma-grade 4-chloroaniline (CAS 106-47-8, ≥99%) as a key intermediate for paracetamol-class APIs, dye coupling and rubber accelerator (CBS) synthesis. GMP-friendly Nanjing plant.
Structure
Identifiers
CAS:
106-47-8HS:
29214210EC:
203-401-0IUPAC name: 4-chloroaniline
Formula:
C6H6ClNMW: 127.57 g/mol
Specifications
Grade: pharma-grade
Purity: ≥99%
Appearance: White to light cream crystalline flakes; slightly aromatic odour.
Commercial
Price: 6.2–8.8 USD/kg
Lead time: 14–28 days
Inventory: to order (6000 kg)
Safety & compliance
UN 2018 · Hazmat 6.1 (Toxic Solid, PG II) · REACH registered
Sold by
Spec sheet
| Parameter | Value |
|---|---|
| Assay (HPLC) | ≥ 99.0% |
| Melting point | 70–72°C |
| Boiling point | 232°C |
| Water | ≤ 0.10% |
| Iron (Fe) | ≤ 5 ppm |
| 2-Chloroaniline isomer | ≤ 0.20% |
Synthesis route
Manufactured by catalytic hydrogenation of p-chloronitrobenzene over a Pd/C catalyst, followed by vacuum distillation and crystallisation. All key process parameters are logged per batch and available under an MMSA / GMP audit.
Quality documents
- Per-batch CoA (HPLC, KF, residual solvents)
- Genotoxic-impurity statement (PGI < 1.5 ppm)
- Residual-metals statement (ICH Q3D)
- DMF on file with US FDA on request
Hazards & handling
Toxic by inhalation, skin contact and ingestion. Suspected carcinogen (IARC group 2B). Handle under closed transfer; full PPE; respiratory protection mandatory. Store sealed under nitrogen, 2–8°C, away from oxidisers.
Physical & chemical properties
Computed descriptors aggregated from PubChem for CAS 106-47-8.
| XLogP | 1.9 |
|---|---|
| Complexity | 66 |
| Exact mass | 127.0188769 g/mol |
| Formal charge | 0 |
| Heavy atom count | 8 |
| Monoisotopic mass | 127.0188769 g/mol |
| H-bond donor count | 1 |
| Rotatable bond count | 0 |
| H-bond acceptor count | 1 |
| Topological polar surface area (TPSA) | 26 Ų |
China regulatory compliance
Not listed in hazardous / restricted catalogues
Frequently asked questions
Curated by ChemExact's editorial team and reviewed by chemistry and API procurement specialists. Each factual claim is traceable to the cross-source citation graph at the bottom of the page.
What is 4-chloroaniline (CAS 106-47-8)?
4-chloroaniline is a chemical compound with molecular formula C6H6ClN and molecular weight ≈ 127.57 g/mol. Its CAS Registry Number is 106-47-8. p-Chloroaniline can cause cancer according to The World Health Organization's International Agency for Research on Cancer (IARC).
What is the molecular formula and weight of 4-chloroaniline (CAS 106-47-8)?
The molecular formula of 4-chloroaniline is C6H6ClN, and the molecular weight is 127.57 g/mol. This data has been cross-verified against PubChem, ChEMBL and CAS Common Chemistry.
What are the SMILES and InChIKey of 4-chloroaniline?
The canonical SMILES of 4-chloroaniline is `C1=CC(=CC=C1N)Cl`, and the InChIKey is `QSNSCYSYFYORTR-UHFFFAOYSA-N`. These international identifiers are reusable in PubChem, ChemDraw, RDKit and most cheminformatics toolchains.
What are the common synonyms of 4-chloroaniline?
Common synonyms of 4-chloroaniline include: 4-CHLOROANILINE, 106-47-8, p-Chloroaniline, 4-Chlorobenzenamine, 4-Chlorophenylamine, p-Chloraniline, Benzenamine, 4-chloro-, 1-Amino-4-chlorobenzene — 20 synonyms in total. The full list (sourced from PubChem) is available in the page header under "Show synonyms".
What is the current market price of 4-chloroaniline (CAS 106-47-8)?
ChemExact follows a claimed-supplier real-time pricing model: when a verified supplier claims this product page, the right sidebar shows their public quote, MOQ and validity. Current page status: UNCLAIMED — suppliers welcome to onboard and quote. For market reference, see weekly bulletins from ICIS (icis.com), S&P Global Commodity Insights, or China-side aggregators (Longzhong, Sublime, BAIINFO).
How has 4-chloroaniline price trended recently?
4-chloroaniline pricing typically tracks upstream feedstocks (oil, propylene/aromatics), export demand and seasonal turnaround schedules. Authoritative trackers include: ① ICIS weekly reports; ② S&P Global Platts; ③ China General Administration of Customs (GACC) export data; ④ China Petroleum & Chemical Industry Federation (CPCIF) monthly bulletins. ChemExact will aggregate public weekly bulletins as a market-reference layer (no quote-binding) in subsequent sprints.
Who are the major manufacturers of 4-chloroaniline in China?
Authoritative public sources for finding licensed Chinese manufacturers of 4-chloroaniline: ① China MEM Hazardous Chemicals Registration System — https://whpdj.mem.gov.cn/ (searchable registered enterprises); ② China Chemical Information Center (CCIN) industry database — http://www.ccin.com.cn/; ③ Public B2B platforms such as Made-in-China.com and Alibaba 1688 (with verified-supplier filters). ChemExact will aggregate the public regulatory lists into a 'potential suppliers' candidate pool (with full provenance) in the next sprint.
Who are the largest global producers of 4-chloroaniline?
Global supply discovery for 4-chloroaniline is best started from public regulatory registries: ① ECHA REACH registered companies — https://echa.europa.eu/information-on-chemicals (by CAS 106-47-8 returns all EU-compliant registrants); ② US EPA CompTox Chemicals Dashboard — https://comptox.epa.gov/dashboard/; ③ Japan NITE Chemical Risk Information Platform (CHRIP). These registries list compliant producers/importers and serve as a credible first-pass shortlist for international procurement.
What grades of 4-chloroaniline are commercially available?
4-chloroaniline is typically supplied in the following grades: Industrial / Technical (≥ 99%, bulk feedstock), Reagent (AR/CP/GR, ≥ 99.5%, lab analytics), HPLC / GC (≥ 99.9%, chromatography & spectroscopy). Grade-specific specs are confirmed via the supplier's SDS and CoA. ChemExact lets verified suppliers attach hash-validated CoA/SDS files to their claimed product pages.
Where can I download the SDS / MSDS for 4-chloroaniline (CAS 106-47-8)?
Authoritative SDS sources: ① PubChem 'Safety and Hazards' section — https://pubchem.ncbi.nlm.nih.gov/compound/7812; ② US NIH Hazardous Substances Data Bank (HSDB); ③ ECHA REACH dossier; ④ Supplier-attached SDS on the claimed product page. ChemExact does not host SDS files directly (to avoid version drift); all SDS links route to source.
What should be included in a Certificate of Analysis (CoA) for 4-chloroaniline?
A typical industrial CoA for an organic chemical includes: assay (GC%), appearance, density, refractive index, water content (Karl Fischer), acidity, distillation range or boiling point, heavy metals, and iron content. Reagent / pharma grades additionally provide IR / NMR / HPLC traces. ChemExact requires verified suppliers to upload a CoA template upon claiming, so buyers can perform back-validation.
What is the HS code and import procedure for 4-chloroaniline?
Authoritative trade lookups: ① China Customs Tariff (Single Window) — https://www.singlewindow.cn; ② US ITC HTS — https://hts.usitc.gov/; ③ EU TARIC — https://taric.ec.europa.eu/. ChemExact will integrate GACC's public HS code dataset in Sprint 4.
Related research papers
Open-access publications referencing 4-Chloroaniline (PCA) (CAS 106-47-8), sourced from OpenAlex.
Characteristics and adsorption capacities of low-cost sorbents for wastewater treatment: A review
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Chemicals from Alkynes with Palladium Catalysts
The chemistry of isatins: a review from 1975 to 1999
Adsorptive separation on metal–organic frameworks in the liquid phase
Content & data statement.
Commercial information on this page (CAS, HS, EC, purity grade, indicative price band, lead time, inventory status,
REACH and FDA flags) is captured from supplier-controlled documents by the ChemExact editorial desk and reviewed
on a recurring cycle. Chemistry data — structures, synonyms, physico-chemical properties, hazard classifications and
the cited literature — is reconciled against internationally recognised authorities (including but not limited to
PubChem, CAS Common Chemistry, ECHA, China MEM, ChEMBL and OpenAlex) and cross-checked by our editors.
Disclaimer: This page is intended as a procurement-side technical reference and does not constitute legal, regulatory, or medical advice. Lot-level conformity is determined by the supplier-signed CoA and SDS. Transport, storage and handling must follow the applicable jurisdictional regulations and product SDS. If you spot a discrepancy with an authoritative source, please contact our editorial team — we review correction requests within five business days.
Disclaimer: This page is intended as a procurement-side technical reference and does not constitute legal, regulatory, or medical advice. Lot-level conformity is determined by the supplier-signed CoA and SDS. Transport, storage and handling must follow the applicable jurisdictional regulations and product SDS. If you spot a discrepancy with an authoritative source, please contact our editorial team — we review correction requests within five business days.
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